Precision Oncology

Diagnostic Radioisotopes

B. J. Madan & Co. is the authorized agent for ITM Medical Isotopes GmbH, Germany in India.

• ITM ⁶⁸Ge/⁶⁸Ga GENERATOR

⁶⁸Ga PET imaging has proven to be a superior method for precise localization of tumor cells and metastatic lesions. With the GMP certification of our ITM ⁶⁸Ge/⁶⁸Ga Generator we have set yet another milestone in order to establish ⁶⁸Ga as next generation radioisotope for diagnostic purpose. The generator columns unique metal free design and its low acidic eluent allow the fast and convenient onsite production of short-lived high-quality ⁶⁸Ga for radiolabeling without prior prepurification.

KEY ADVANTAGES

• Fast and convenient labelling of PET tracers
• Metal free matrix allows direct labelling
• Low acidic eluent (0.05 M HCl)
• Small elution volume (4ml)

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• Targeted Radionuclide Therapy in Precision Oncology

Precision oncology has made progress in leaps and bounds in recent years and is currently at the heart of revolutionizing cancer research. As this research continues to develop and evolve, the enhanced use of precision oncology in cancer treatment ultimately aims to improve prognosis and outcomes for patients. Precision Oncology is an innovative approach to cancer treatment that ensures the treatment is specifically designed and targeted to the unique form of cancer.

Peptide Receptor Radionuclide Therapy (PRRT) a form of molecular targeted therapy is performed by using a small peptide that is coupled with a radionuclide. PRRT is a novel nuclear medicine therapy for the systemic treatment of metastasized tumors.

• EndolucinBeta^® – n.c.a. ¹⁷⁷ Lu Chloride

EndolucinBeta^® 40 GBq/mL Radiopharmaceutical Precursor Solution.
EndolucinBeta^® is a radiopharmaceutical precursor used in Targeted Radionuclide Therapy for the treatment of various diseases, like cancer. When labeled with a disease-specific carrier molecule (e.g. peptide or antibody), the targeted radiopharmaceutical binds to a tumor specific receptor, according to the lock and key principle. EndolucinBeta® has a half-life of 6.647 days.

Active substance: no-carrier-added (n.c.a.) Lutetium-177 (¹⁷⁷Lu) chloride

Marketing Authorization Holder: ITM Medical Isotopes GmbH. A company of the ITM Group.

Package leaflet: Information for the patient
Additional information for Healthcare Professionals

www.itm-radiopharma.com/

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• Actinium-225

Alpha Emitter with short Penetration Range
Actinium-225 (²²⁵Ac) is an alpha-emitting radioisotope with a half-life of 9.920 days. It is characterized by an extremely short penetration range of alpha particles and a high linear energy transfer (LET).
₂₂₅Ac is delivered in 2 mL V-shape vial as a solution in 0.1 M hydrochloric acid with a Chemical purity: > 99.9 % ₂₂₅Ac

• ¹⁸⁸W/¹⁸⁸Re Generator

B. J. Madan & Co. is the authorized agent for OncoBeta Gmbh, Germany in India.

Production of high-energy beta emitting rhenium-188

Product Overview
The OncoBeta^® ₁₈₈W/₁₈₈Re Generator is based on an alumina column. The longer-lived mother radionuclide ₁₈₈W is adsorbed on the column material while the daughter radionuclide ₁₈₈Re is selectively eluted from the generator with sterile isotonic solution as sodium perrhenate (Na₁₈₈ReO4).

Use Cases
The ₁₈₈W/₁₈₈Re Generator can be used for radiolabelling reactions or directly as a high dose liquid radioactive source.

Main Features
> Available in different sizes upon request up to 150 GBq (4 Ci) ₁₈₈W
> High activity concentration > Up to 9 GBq/ml

https://www.oncobeta.com/wolfram-rhenium-generator-de/

Specifications

Column material	Aluminium oxide (Al2O3) packed in quartz glass column
Eluent	Sterile 0.9% saline solution
Chemical form	Sodium perrhenate (Na188ReO4)
Appearance	Clear and colorless solution
Elution volume	5-14 ml (with small volumes not completed elution)
Elution yield	75-85%
Radiochemical purity	>98% Re(VII)
Tungsten breakthrough	188W <0.01% in relation to 188Re at calibration time
Total gamma impurities	<0.01% in relation to 188Re at calibration time
Shelf-life	10 months
Specific activity	Product is carrier free
Generator size (nominal 188W activity)	3.7-150 GBq
Generator dimensions	Diameter 145 mm, height 210 mm
Generator weight	16 kg
Interface Standard	Stainless steel needles for elution with evacuated vials. On request: Tubings with Luer-Lock connectors (inlet female, outlet male)

• Sodium Iodide I-131 solution

Radioactive Iodine (I-131) Therapy. Radioiodine therapy is a nuclear medicine treatment for an overactive thyroid, a condition called hyperthyroidism, and also may be used to treat thyroid cancer.